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Items: 3

1.

Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle micro RNAs

(Submitter supplied) Background: Mesenchymal stem cells (MSCs) and macrophages are fundamental components of the stem cell niche and function coordinately to regulate hematopoietic stem cell self-renewal and mobilization. Recent studies indicate that mitophagy and healthy mitochondrial function are critical to the survival of stem cells but how these processes are regulated in MSCs is unknown. Here we show that MSCs manage intracellular oxidative stress by targeting depolarized mitochondria to the plasma membrane via arrestin domain-containing protein 1-mediated microvesicles , which are then engulfed and re-utilized via a process involving fusion by macrophages resulting in enhanced bio-energetics. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL18743
18 Samples
Download data: TXT
Series
Accession:
GSE71241
ID:
200071241
2.

Agilent-021827 Human miRNA Microarray [miRNA_107_Sep09]

(Submitter supplied) Table corresponds to miRNA_107_Sep09 Agilent Feature Extraction file. Protocol: See manufacturer's web site at http://www.agilent.com/
Organism:
Homo sapiens
3 Series
49 Samples
Download data
Platform
Accession:
GPL18743
ID:
100018743
3.

Human Mesencyhmal Stem Cells (which exosomes were derived from) sample 3 replicate 3

Organism:
Homo sapiens
Source name:
Human MSC from which exosomes were derived
Platform:
GPL18743
Series:
GSE71241
Download data: TXT
Sample
Accession:
GSM1831311
ID:
301831311
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