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Items: 4

1.

Spontaneous single-copy loss of TP53 in human embryonic stem cells markedly increases cell proliferation and survival

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; SNP genotyping by SNP array
Platforms:
GPL14157 GPL16791
16 Samples
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Series
Accession:
GSE70875
ID:
200070875
2.

Spontaneous single-copy loss of TP53 in human embryonic stem cells markedly increases cell proliferation and survival [RNA-Seq]

(Submitter supplied) The potential safety issues related to the acquisition of common genomic aberrations in hPSC cultures are well-recognized, but these risks have not been evaluated for sporadic mutations. Here, we explore whether a sporadic mutation that spontaneously arose in a hESC culture consisting of a single-copy deletion of chr17p13.1 would confer a survival advantage to the mutant cells. Compared to wild-type cells with two normal copies of the chr17p13.1 region, the mutant cells displayed a selective advantage when exposed to stressful conditions, and retained a higher percentage of pluripotent cells after two weeks of in vitro differentiation. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
12 Samples
Download data: XLSX
Series
Accession:
GSE70874
ID:
200070874
3.

Illumina HiSeq 2500 (Homo sapiens)

Platform
Accession:
GPL16791
ID:
100016791
4.

Wild-type1_1

Organism:
Homo sapiens
Source name:
Wild-type1_1
Platform:
GPL16791
Series:
GSE70874 GSE70875
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Sample
Accession:
GSM1821008
ID:
301821008
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