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Items: 4

1.

Expression profiling of MCF-7 cells with inducible LMO4 and DN-Clim expression

(Submitter supplied) The nuclear LIM-only protein LMO4 is upregulated in breast cancer, especially estrogen receptor negative tumors, and its overexpression in mice leads to hyperplasia and tumor formation. Here, we show that deletion of LMO4 in the mammary glands of mice leads to impaired lobuloalveolar development due to decreased epithelial cell proliferation. With the goal of discovering potential LMO4-target genes, we also developed a conditional expression system in MCF-7 cells for both LMO4 and a dominant negative (DN) form of its co-regulator, Co-factor of LIM domains (Clim/Ldb/Nli). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS2787 GDS2788 GDS2789
Platforms:
GPL96 GPL97 GPL570
18 Samples
Download data: CEL
Series
Accession:
GSE7382
ID:
200007382
2.
Full record GDS2789

LIM homeobox protein cofactor dominant negative form effect on breast cancer cell line

Analysis of breast cancer MCF-7 cells after the induction of expression of a dominant negative form of the cofactor of LIM domains (CLIM), a co-regulator of the nuclear LIM only protein 4 (LMO4). LMO4 is upregulated in breast cancer. Results provide insight into the role of LMO4 in tumor formation.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL570
Series:
GSE7382
6 Samples
Download data: CEL
DataSet
Accession:
GDS2789
ID:
2789
3.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...
Organism:
Homo sapiens
602 DataSets
5651 Series
61 Related Platforms
171341 Samples
Download data
Platform
Accession:
GPL570
ID:
100000570
4.

MCF7 DN-CLIM low Replicate1

Organism:
Homo sapiens
Source name:
MCF7-DN-CLIM-TetOff cells
Platform:
GPL570
Series:
GSE7382
Dataset:
GDS2789
Download data: CEL
Sample
Accession:
GSM177589
ID:
300177589
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db=gds|term=GSM177589[Accession]|query=1|qty=2|blobid=MCID_6652dba26c05354989829258|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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