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Items: 4

1.

Expression profiling of MCF-7 cells with inducible LMO4 and DN-Clim expression

(Submitter supplied) The nuclear LIM-only protein LMO4 is upregulated in breast cancer, especially estrogen receptor negative tumors, and its overexpression in mice leads to hyperplasia and tumor formation. Here, we show that deletion of LMO4 in the mammary glands of mice leads to impaired lobuloalveolar development due to decreased epithelial cell proliferation. With the goal of discovering potential LMO4-target genes, we also developed a conditional expression system in MCF-7 cells for both LMO4 and a dominant negative (DN) form of its co-regulator, Co-factor of LIM domains (Clim/Ldb/Nli). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS2787 GDS2788 GDS2789
Platforms:
GPL96 GPL97 GPL570
18 Samples
Download data: CEL
Series
Accession:
GSE7382
ID:
200007382
2.
Full record GDS2788

LIM-only protein 4 induction effect on breast cancer cell line (HG-U133B)

Analysis of breast cancer MCF-7 cells following the induction of expression of nuclear LIM-only protein 4 (LMO4). LMO4 is upregulated in breast cancer. Results provide insight into the role of LMO4 in promoting tumor formation.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL97
Series:
GSE7382
6 Samples
Download data: CEL
DataSet
Accession:
GDS2788
ID:
2788
3.

[HG-U133B] Affymetrix Human Genome U133B Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 21, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The U133 set includes 2 arrays with a total of 44928 entries and was indexed 29-Jan-2002. more...
Organism:
Homo sapiens
51 DataSets
165 Series
2 Related Platforms
7917 Samples
Download data
Platform
Accession:
GPL97
ID:
100000097
4.

MCF7 LMO4 low Replicate2B

Organism:
Homo sapiens
Source name:
MCF7-LMO4-TetOff cells
Platform:
GPL97
Series:
GSE7382
Dataset:
GDS2788
Download data: CEL
Sample
Accession:
GSM177584
ID:
300177584
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db=gds|term=GSM177584[Accession]|query=1|qty=2|blobid=MCID_6653baf26c05354989925883|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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