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Items: 4

1.

Oncogenic deregulation of EZH2 as an opportunity for targeted therapy in lung cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL19057
19 Samples
Download data: TXT, WIG
Series
Accession:
GSE70047
ID:
200070047
2.

Oncogenic deregulation of EZH2 as an opportunity for targeted therapy in lung cancer [ChIP-Seq]

(Submitter supplied) As a master regulator of chromatin structure and function, the EZH2 lysine methyltransferase orchestrates transcriptional silencing of developmental gene networks. Overexpression of EZH2 is commonly observed in human epithelial cancers, such as non- small cell lung carcinoma (NSCLC), yet definitive demonstration of malignant transformation by deregulated EZH2 has proven elusive. Here, we demonstrate the causal role of EZH2 overexpression in NSCLC with a new genetically-engineered mouse model of lung adenocarcinoma. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL19057
12 Samples
Download data: WIG
Series
Accession:
GSE70045
ID:
200070045
3.

Illumina NextSeq 500 (Mus musculus)

Platform
Accession:
GPL19057
ID:
100019057
4.

Lung_HZ54_H3K27me3

Organism:
Mus musculus
Source name:
Lung
Platform:
GPL19057
Series:
GSE70045 GSE70047
Download data: WIG
Sample
Accession:
GSM1716265
ID:
301716265
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Supplemental Content

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