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Items: 4

1.

Pancreatic Beta Cell Enhancers Regulate Rhythmic Transcription of Exocyst Triggering and Diabetes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL17021 GPL18573 GPL19057
68 Samples
Download data: TXT
Series
Accession:
GSE70961
ID:
200070961
2.

Genome-wide Circadian Control of Transcription at Active Enhancers Regulates Insulin Secretion and Diabetes Risk

(Submitter supplied) The molecular clock is a transcriptional oscillator present in brain and peripheral cells that coordinates behavior and physiology with the solar cycle. Here we reveal that the clock gates insulin secretion through genome-wide transcriptional control of the pancreatic exocyst across species. Clock transcription factors bind to unique enhancer sites in cycling genes in beta cells that diverge from those in liver, revealing the dynamics of inter-tissue clock control of genomic and physiologic processes important in glucose homeostasis.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL17021 GPL18573 GPL19057
60 Samples
Download data: TXT
Series
Accession:
GSE69889
ID:
200069889
3.

Illumina NextSeq 500 (Mus musculus)

Platform
Accession:
GPL19057
ID:
100019057
4.

Mouse islet polyA RNA-Seq biological replicate 3 CT36

Organism:
Mus musculus
Source name:
C57BL/6 wild type mice
Platform:
GPL19057
Series:
GSE69889 GSE70961
Download data
Sample
Accession:
GSM1711998
ID:
301711998
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Supplemental Content

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