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Items: 3

1.

Regulatory landscape fusion in rhabdomyosarcoma by interactions between the PAX3 promoter and FOXO1 regulatory elements

(Submitter supplied) Results: Using a combination of 4C-seq datasets, we were able to model the three-dimensional organisation of the translocated chromosome in a PAX3:FOXO1 fusion-positive alveolar rhabdomyosarcoma cell line. We show that PAX3 and FOXO1 regulatory landscapes fuse into a novel TAD, allowing the PAX3 promoter to interact ectopically with FOXO1 sequences with potential enhancer function. The borders of this novel TAD correspond to the original 5'- and 3'- borders of the PAX3 and FOXO1 TADs, respectively, suggesting that TAD organisation precedes the formation of regulatory long-range interactions. more...
Organism:
Homo sapiens; Mus musculus
Type:
Other
Platforms:
GPL11154 GPL13112 GPL16791
11 Samples
Download data: BEDGRAPH
Series
Accession:
GSE69439
ID:
200069439
2.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
3.

4C-Seq for PAX3 promoter in patient-derived RMS cells

Organism:
Homo sapiens
Source name:
RMS cell line
Platform:
GPL11154
Series:
GSE69439
Download data: BEDGRAPH
Sample
Accession:
GSM1701247
ID:
301701247
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db=gds|term=GSM1701247[Accession]|query=1|qty=3|blobid=MCID_67aa046a750a117a1d462991|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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