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Items: 3

1.

Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B-cell progenitors

(Submitter supplied) In order to investigate how transcription factor dose impacts B-lymphocyte development, we generated mice carrying transheterozygous mutations in the Pax5 and Ebf1 genes. While combined reduction of Pax5 and Ebf1 dose had minimal impact on the development of the earliest CD19+ progenitors, these cells displayed an increased T-cell potential in vivo and in vitro. Alteration in lineage fate depended on a Notch1 mediated conversion process while no signs of de-differentiation could be detected. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL17021 GPL19057
36 Samples
Download data: BED
Series
Accession:
GSE69227
ID:
200069227
2.

Illumina NextSeq 500 (Mus musculus)

Platform
Accession:
GPL19057
ID:
100019057
3.

RNA-seq WT-ProB cultured 1 day on OP9, rep4

Organism:
Mus musculus
Source name:
WT ProB, 1 day culture on OP9 stromal cells
Platform:
GPL19057
Series:
GSE69227
Download data: BED
Sample
Accession:
GSM1695687
ID:
301695687
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