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Items: 3

1.

Small and large RNA sequencing of mouse livers receiving small hairpin RNAs

(Submitter supplied) Adeno-associated viral (AAV) small hairpin (shRNA) expression vectors are a promising therapeutic but can induce severe liver toxicity when delivered at high albeit undefined doses. Using various AAV-shRNA vectors under the high-expressing U6 and low-expressing H1 promoters, we found that dose-limiting toxicity was strongly correlated with an shRNA concentration of >12% of total microRNA levels. Toxicity was associated with a specific reduction in the first synthesized 22nt isoform of miR-122-5p, resulting in the specific de-repression of miR-122 target mRNAs. more...
Organism:
Mus musculus; Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing
4 related Platforms
107 Samples
Download data: TXT
Series
Accession:
GSE69186
ID:
200069186
2.

Illumina Genome Analyzer II (Mus musculus)

Platform
Accession:
GPL9250
ID:
100009250
3.

H1_sh_hAAT_21nt_rep1_total

Organism:
Mus musculus
Source name:
liver - total RNA
Platform:
GPL9250
Series:
GSE69186
Download data
Sample
Accession:
GSM1695034
ID:
301695034
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