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Items: 4

1.

Activation of proto-oncogenes by disruption of chromosome neighborhoods

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
Platforms:
GPL16791 GPL15520 GPL11154
22 Samples
Download data: BED12, WIG
Series
Accession:
GSE68978
ID:
200068978
2.

Activation of proto-oncogenes by disruption of chromosome neighborhoods [ChIP-Seq]

(Submitter supplied) Mutations such as gene fusion, translocation and focal amplification are a frequent cause of proto-oncogene activation during tumorigenesis, but such mutations do not explain all cases of proto-oncogene activation. Here we show that disruption of local chromosome conformation can also activate proto-oncogenes in human cells. We mapped chromosome structures in T-cell acute lymphoblastic leukemia (T-ALL), and found that active oncogenes and silent proto-oncogenes generally occur within insulated neighborhoods formed by the looping of two interacting CTCF sites co-occupied by cohesin. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL16791 GPL11154
10 Samples
Download data: WIG
Series
Accession:
GSE68976
ID:
200068976
3.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
4.

Jurkat_CTCF_ChIP

Organism:
Homo sapiens
Source name:
T-ALL
Platform:
GPL11154
Series:
GSE68976 GSE68978
Download data: WIG
Sample
Accession:
GSM1689152
ID:
301689152
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Supplemental Content

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