GSM1683489[Accession] - GEO DataSets

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Items: 4

Select item 2000688471.

BRCA1, R-loops and Recombination defects in Ewing's sarcoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Other; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL21290 GPL11154
79 Samples

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Accession:: GSE68847

ID:: 200068847

PubMed Full text in PMC Similar studies

Select item 2000688452.

BRCA1, R-loops and Recombination defects in Ewing's sarcoma (DRIP-seq)

(Submitter supplied) Ewing’s sarcoma family of tumors (ESFT) is an aggressive pediatric bone and soft tissue cancer. It is the prototypical example of mesenchymal tumors driven by a fusion oncogene involving the ewing sarcoma break point region 1 (EWSR1) gene, most frequently– EWS-FLI1. We have discovered that loss of EWSR1 leads to accumulation of R-loops, replication stress and impaired homologous recombination, recapitulating breast cancer 1, early onset (BRCA1) deficiency. more...