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Items: 3

1.

Sequential Notch activation regulates ventricular chamber development

(Submitter supplied) Ventricular chambers are essential for the rhythmic contraction and relaxation that occurs in every hearbeat throughout life. Congenital abnormalities in ventricular chamber formation cause severe human heart defects. How the early trabecular meshwork of myocardial fibres forms and subsequently develops into mature chambers is still poorly understood. Here we show that Notch signalling first connects chamber endocardium and myocardium to sustain trabeculation and later coordinates ventricular patterning and compaction with coronary vessel development to give rise to the mature chamber via a temporal sequence of ligand signalling determined by the glycosyltransferase Manic Fringe (Mfng). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL11002 GPL17021
43 Samples
Download data: CSV, TXT
Series
Accession:
GSE67889
ID:
200067889
2.

Illumina Genome Analyzer IIx (Mus musculus)

Platform
Accession:
GPL11002
ID:
100011002
3.

Notch1WT-Nfat_1

Organism:
Mus musculus
Source name:
whole hearts of 8 embryos
Platform:
GPL11002
Series:
GSE67889
Download data
Sample
Accession:
GSM1657611
ID:
301657611
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db=gds|term=GSM1657611[Accession]|query=1|qty=2|blobid=MCID_669aebd856cb0a044ea1755c|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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