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Items: 3

1.

ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate

(Submitter supplied) In order to propagate a solid tumor, cancer cells must adapt to and survive under various tumor microenvironment (TME) stresses, such as hypoxia or lactic acidosis. To systematically identify genes that modulate cancer cell survival under stresses, we performed genome-wide shRNA screens under hypoxia or lactic acidosis. We discovered that genetic depletion of acetyl-CoA carboxylase (ACACA or ACC1) or ATP citrate lyase (ACLY) protected cancer cells from hypoxia-induced apoptosis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
22 Samples
Download data: CEL
Series
Accession:
GSE61286
ID:
200061286
2.

[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 08, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The GeneChip Human Genome U133A 2.0 Array is a single array representing 14,500 well-characterized human genes that can be used to explore human biology and disease processes. more...
Organism:
Homo sapiens
84 DataSets
638 Series
12 Related Platforms
24352 Samples
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Platform
Accession:
GPL571
ID:
100000571
3.

shACC1-#2_rep2

Organism:
Homo sapiens
Source name:
H1975 cells, shshACC1, 24h hypoxia
Platform:
GPL571
Series:
GSE61286
Download data: CEL
Sample
Accession:
GSM1629320
ID:
301629320
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