GSM1588917[Accession] - GEO DataSets

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Items: 4

Select item 2000651861.

Non-genomic and Immune Evolution in Melanoma with Acquired MAPKi Resistance

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Expression profiling by high throughput sequencing; Methylation profiling by genome tiling array

Platforms:: GPL11154 GPL17692 GPL13534
218 Samples

Download data: CEL, IDAT

Series

Accession:: GSE65186

ID:: 200065186

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000651852.

RNAseq changes in pre MAPKi treatment and post MAPKi resistance Melanomas

(Submitter supplied) Melanoma resistance to MAPK- or T cell checkpoint-targeted therapies represents a major clinical challenge, and treatment failures of MAPK-targeted therapies due to acquired resistance often require salvage immunotherapies. We show that genomic analysis of acquired resistance to MAPK inhibitors revealed key driver genes but failedto adequately account for clinical resistance. From a large-scale comparative analysis of temporal transcriptomes from patient-matched tumor biopsies, we discovered highly recurrent differential expression and signature outputs of c-MET, LEF1 and YAP1 as drivers of acquired MAPK inhibitor resistance. more...