U.S. flag

An official website of the United States government

Format
Sort by

Send to:

Choose Destination

Search results

Items: 4

1.

Non-genomic and Immune Evolution in Melanoma with Acquired MAPKi Resistance

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Expression profiling by high throughput sequencing; Methylation profiling by genome tiling array
Platforms:
GPL11154 GPL17692 GPL13534
218 Samples
Download data: CEL, IDAT
Series
Accession:
GSE65186
ID:
200065186
2.

RNAseq changes in pre MAPKi treatment and post MAPKi resistance Melanomas

(Submitter supplied) Melanoma resistance to MAPK- or T cell checkpoint-targeted therapies represents a major clinical challenge, and treatment failures of MAPK-targeted therapies due to acquired resistance often require salvage immunotherapies. We show that genomic analysis of acquired resistance to MAPK inhibitors revealed key driver genes but failedto adequately account for clinical resistance. From a large-scale comparative analysis of temporal transcriptomes from patient-matched tumor biopsies, we discovered highly recurrent differential expression and signature outputs of c-MET, LEF1 and YAP1 as drivers of acquired MAPK inhibitor resistance. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
70 Samples
Download data: TXT
3.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
4.

Pt19-baseline

Organism:
Homo sapiens
Source name:
tumor biopsy
Platform:
GPL11154
Series:
GSE65185 GSE65186
Download data
Sample
Accession:
GSM1588897
ID:
301588897
Format
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=GSM1588897[Accession]|query=1|qty=2|blobid=MCID_65de8167a642ff6770017853|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Search details

See more...

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center