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Items: 4

1.

Non-genomic and Immune Evolution in Melanoma with Acquired MAPKi Resistance

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Expression profiling by high throughput sequencing; Methylation profiling by genome tiling array
Platforms:
GPL17692 GPL13534 GPL11154
218 Samples
Download data: CEL, IDAT
Series
Accession:
GSE65186
ID:
200065186
2.

Methylation changes in pre MAPKi treatment and post MAPKi resistance Melanomas

(Submitter supplied) Melanoma resistance to MAPK- or T cell checkpoint-targeted therapies represents a major clinical challenge, and treatment failures of MAPK-targeted therapies due to acquired resistance often require salvage immunotherapies. We show that genomic analysis of acquired resistance to MAPK inhibitors revealed key driver genes but failedto adequately account for clinical resistance. From a large-scale comparative analysis of temporal transcriptomes from patient-matched tumor biopsies, we discovered highly recurrent differential expression and signature outputs of c-MET, LEF1 and YAP1 as drivers of acquired MAPK inhibitor resistance. more...
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL13534
144 Samples
Download data: IDAT
Series
Accession:
GSE65183
ID:
200065183
3.

Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)

(Submitter supplied) 1 difference between HumanMethylation450_15017482_v.1.1.bpm and HumanMethylation450_15017482_v.1.2.bpm: 1.1: 41636384,NEGATIVE,-99,Negative 604 1.2: 41636384,RESTORATION,Green,Restore Protocol: See manufacturer's website
Organism:
Homo sapiens
1661 Series
1 Related Platform
117595 Samples
Download data: BPM, CSV, TXT, XLSX
Platform
Accession:
GPL13534
ID:
100013534
4.

Pt17-baseline-1

Organism:
Homo sapiens
Source name:
tumor biopsy
Platform:
GPL13534
Series:
GSE65183 GSE65186
Download data: IDAT
Sample
Accession:
GSM1588792
ID:
301588792
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Supplemental Content

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