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Items: 4

1.

Mediator kinase inhibition further activates super-enhancer-associated genes in AML

(Submitter supplied) Super-enhancers (SEs), which are composed of large clusters of enhancers densely loaded with the Mediator complex, transcription factors and chromatin regulators, drive high expression of genes implicated in cell identity and disease, such as lineage-controlling transcription factors and oncogenes. BRD4 and CDK7 are positive regulators of SE-mediated transcription. By contrast, negative regulators of SE-associated genes have not been well described. more...
Organism:
Homo sapiens
Type:
Expression profiling by array; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
5 related Platforms
89 Samples
Download data: CEL
Series
Accession:
GSE65161
ID:
200065161
2.

Effect of cortistatin A (CA) on enhancer occupancy in CA-sensitive and -insensitive human cell lines

(Submitter supplied) We characterized the marine natural product cortistatin A (CA) as an inhibitor of CDK8 to determine whether pharmacologic inhibition of CDK8 regulates super-enhancer function and inhibits AML proliferation. In this series, we use ChIP-seq of H3K27ac, H3K4me1, MED1, CDK8, BRD4, and RNA polymerase II (PolII) to examine enhancer occupancy and transcriptional response to CA in human cells lines.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL18573 GPL16791
53 Samples
Download data: BED, XLSX
Series
Accession:
GSE65138
ID:
200065138
3.

Illumina NextSeq 500 (Homo sapiens)

Platform
Accession:
GPL18573
ID:
100018573
4.

MOLM14_H3K27ac_DMSO_9

Organism:
Homo sapiens
Source name:
MOLM14
Platform:
GPL18573
Series:
GSE65138 GSE65161
Download data
Sample
Accession:
GSM1587909
ID:
301587909
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