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Items: 4

1.

Scl specifies hemogenic endothelium and inhibits cardiogenesis via primed enhancers

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Expression profiling by array; Methylation profiling by high throughput sequencing
Platforms:
GPL1261 GPL13112
47 Samples
Download data: BW, CEL, GTF
Series
Accession:
GSE47085
ID:
200047085
2.

Scl specifies hemogenic endothelium and inhibits cardiogenesis via primed enhancers [ChIP-seq]

(Submitter supplied) Scl/Tal1 confers hemogenic competence and prevents cardiomyogenesis in embryonic endothelium. Here we show that Scl both directly activates a broad gene regulatory network required for hematopoietic stem/progenitor cell (HS/PC) development, and represses transcriptional regulators required for cardiogenesis. Cardiac repression occurs during a short developmental window through Scl binding to distant cardiac enhancers that harbor H3K4me1 at this stage. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
34 Samples
Download data: BW
Series
Accession:
GSE47082
ID:
200047082
3.

Illumina HiSeq 2000 (Mus musculus)

Platform
Accession:
GPL13112
ID:
100013112
4.

SclKO-iScl_ES_Scl_rep2

Organism:
Mus musculus
Source name:
ES cells
Platform:
GPL13112
Series:
GSE47082 GSE47085
Download data: BW
Sample
Accession:
GSM1543573
ID:
301543573
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