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Items: 3

1.

An Oncogenic Super-Enhancer Formed through Somatic Mutation of a Noncoding Intergenic Element

(Submitter supplied) In many cancers, critical oncogenes are driven from large regulatory elements, called super-enhancers, which recruit much of the cell’s transcriptional apparatus and are defined by extensive H3K27 acetylation. We found that in T-cell acute lymphoblastic leukemia (T-ALL), somatic heterozygous mutations introduce MYB binding motifs in a precise noncoding site, which nucleate a super-enhancer upstream of the TAL1 oncogene. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL16791 GPL11154 GPL9115
20 Samples
Download data: WIG
Series
Accession:
GSE59657
ID:
200059657
2.

Illumina HiSeq 2500 (Homo sapiens)

Platform
Accession:
GPL16791
ID:
100016791
3.

ChIP:MYB_ab45150_Jurkat3_091914 [lab: Look-DFCI]

Organism:
Homo sapiens
Source name:
T-ALL
Platform:
GPL16791
Series:
GSE59657
Download data: WIG
Sample
Accession:
GSM1519641
ID:
301519641
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