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Items: 3

1.

B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity

(Submitter supplied) The antibody gene mutator AID promiscuously damages oncogenes and B cell identity genes leading to chromosomal translocations and tumorigenesis. Why non-immunoglobulin loci are susceptible to AID activity is unknown. Here we study AID-mediated lesions in the context of nuclear architecture and the B cell regulome. We show that AID targets are not randomly distributed across the genome, but are predominantly clustered within super-enhancers. more...
Organism:
Homo sapiens; Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Other
4 related Platforms
76 Samples
Download data: BED, BW, TAB, WIG
Series
Accession:
GSE62063
ID:
200062063
2.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
3.

H3K4me3_AIDmm_clone12

Organism:
Homo sapiens
Source name:
RAMOS
Platform:
GPL11154
Series:
GSE62063
Download data
Sample
Accession:
GSM1519192
ID:
301519192
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db=gds|term=GSM1519192[Accession]|query=1|qty=3|blobid=MCID_661b322fe3fccf293781358b|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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