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Items: 3

1.

Regulation of alternative cleavage and polyadenylation by 3’ end processing and splicing factors

(Submitter supplied) Alternative cleavage and polyadenylation (APA) results in mRNA isoforms containing different 3’ untranslated regions (3’UTRs) and/or coding sequences. How core cleavage and polyadenylation (C/P) factors regulate APA is not well understood. Using siRNA knockdown coupled with deep sequencing, we found that several C/P factors can play significant roles in 3’UTR-APA. Whereas Pcf11 and Fip1 enhance usage of proximal poly(A) sites (pAs), CFI-25/68, PABPN1, and PABPC1 promote usage of distal pAs. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL13112 GPL9250 GPL17021
54 Samples
Download data: TXT
Series
Accession:
GSE62001
ID:
200062001
2.

Illumina Genome Analyzer II (Mus musculus)

Platform
Accession:
GPL9250
ID:
100009250
3.

siCFI-59.1

Organism:
Mus musculus
Source name:
knock down CFI-59 in proliferating C2C12 cells
Platform:
GPL9250
Series:
GSE62001
Download data
Sample
Accession:
GSM1518083
ID:
301518083
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