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Items: 4

1.

Divergent transcriptional activation by glucocorticoids in mouse and human macrophages is the result of gain and loss of enhancers

(Submitter supplied) Macrophages are amongst the major targets of glucocorticoids (GC) as therapeutic anti-inflammatory agents. Here we show that GC treatment of mouse and human macrophages initiates a cascade of induced gene expression including many anti-inflammatory genes. Inducible binding of the glucocorticoid receptor (GR) was detected at candidate enhancers in the vicinity of induced genes in both species and this was strongly associated with canonical GR binding motifs. more...
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing
4 related Platforms
52 Samples
Download data: CEL
Series
Accession:
GSE61881
ID:
200061881
2.

Expression data from a 24h time series of dexamethasone treatment for mouse bone marrow derived macrophages

(Submitter supplied) Macrophages are amongst the major targets of glucocorticoids (GC) as therapeutic anti-inflammatory agents. Here we show that GC treatment of mouse and human macrophages initiates a cascade of induced gene expression including many anti-inflammatory genes. Inducible binding of the glucocorticoid receptor (GR) was detected at candidate enhancers in the vicinity of induced genes in both species and this was strongly associated with canonical GR binding motifs. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11180
18 Samples
Download data: CEL
Series
Accession:
GSE61879
ID:
200061879
3.

[HT_MG-430_PM] Affymetrix HT MG-430 PM Array Plate

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html Protocol: see manufacturer's web site
Organism:
Mus musculus
13 DataSets
285 Series
9 Related Platforms
6973 Samples
Download data
Platform
Accession:
GPL11180
ID:
100011180
4.

BMDM-2h-dex100nM-rep2

Organism:
Mus musculus
Source name:
bone marrow derived macrophage
Platform:
GPL11180
Series:
GSE61879 GSE61881
Download data: CEL
Sample
Accession:
GSM1516142
ID:
301516142
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