GSM1479700[Accession] - GEO DataSets

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Items: 4

Select item 2000606401.

Dicer and Hsp104 function in a negative feedback loop to confer epigenetic robustness

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Schizosaccharomyces pombe

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL13988
9 Samples

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Series

Accession:: GSE60640

ID:: 200060640

PubMed Similar studies

Select item 2000604292.

Dicer and Hsp104 function in a negative feedback loop to confer epigenetic robustness [RNA_profiles]

(Submitter supplied) Epigenetic mechanisms can be influenced by environmental cues and thus evoke phenotypic variation. This plasticity can be advantageous for adaption, but also detrimental if not under tight control. Although having attracted considerable interest, it remains largely unknown if and how environmental cues such as temperature trigger epigenetic alterations. Using fission yeast, we demonstrate that environmentally induced discontinuous phenotypic variation is buffered by a negative feedback loop that involves the RNase Dicer and the protein disaggregase Hsp104. more...