GSM1464563[Accession] - GEO DataSets

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Items: 4

Select item 2000600771.

Length-dependent gene misregulation in Rett syndrome

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Methylation profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

4 related Platforms
38 Samples

Download data: BW, CEL, TXT

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Accession:: GSE60077

ID:: 200060077

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000600712.

Length-dependent gene misregulation in Rett syndrome (ChIP-seq)

(Submitter supplied) Disruption of the MECP2 gene leads to Rett syndrome (RTT), a severe neurological disorder with features of autism. MECP2 encodes a methyl-DNA-binding protein that is proposed to function as a transcriptional repressor, but, despite numerous studies examining neuronal gene expression in MeCP2 mutants, no coherent model has emerged for how MeCP2 regulates transcription. Here we identify a genome-wide length-dependent increase in the expression of long genes in neurons lacking MeCP2. more...