GSM1462554[Accession] - GEO DataSets

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Items: 4

Select item 2000654741.

Physical and functional CSL-p53 interactions underlie control of cancer stromal cell evolution

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL11154 GPL16791
6 Samples

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Accession:: GSE65474

ID:: 200065474

PubMed Full text in PMC Similar studies

Select item 2000599422.

Physical and functional CSL-p53 interactions underlie control of cancer stromal cell evolution [ChIP-seq]

(Submitter supplied) Senescence of stromal fibroblasts has been linked to establishment of cancer associated fibroblasts (CAF) and aging-associated increase of tumors. However, in clinically occurring carcinomas, density and proliferation of CAFs are frequently increased rather than decreased. We previously showed that genetic deletion or down-modulation of the canonical Notch effector CSL/RBP-Jκ in skin dermal fibroblasts is sufficient for CAF activation with consequent development of multifocal keratinocyte tumors. more...