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Items: 3

1.

An Oncogenic Super-Enhancer Formed through Somatic Mutation of a Noncoding Intergenic Element

(Submitter supplied) In many cancers, critical oncogenes are driven from large regulatory elements, called super-enhancers, which recruit much of the cell’s transcriptional apparatus and are defined by extensive H3K27 acetylation. We found that in T-cell acute lymphoblastic leukemia (T-ALL), somatic heterozygous mutations introduce MYB binding motifs in a precise noncoding site, which nucleate a super-enhancer upstream of the TAL1 oncogene. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL16791 GPL11154 GPL9115
20 Samples
Download data: WIG
Series
Accession:
GSE59657
ID:
200059657
2.

Illumina Genome Analyzer II (Homo sapiens)

Platform
Accession:
GPL9115
ID:
100009115
3.

H3K27Ac ChIP RPMI-8402_ChipSeq 11132012_64WVDAAXX_4

Organism:
Homo sapiens
Source name:
T-ALL cell line
Platform:
GPL9115
Series:
GSE59657
Download data: WIG
Sample
Accession:
GSM1442003
ID:
301442003
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db=gds|term=GSM1442003[Accession]|query=1|qty=2|blobid=MCID_67af2b4d1a48797f60e2cc16|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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