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Items: 4

1.

Uridylation by TUT4 and TUT7 marks mRNA for degradation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Other
Platforms:
GPL16791 GPL15520
30 Samples
Download data: TXT
Series
Accession:
GSE59628
ID:
200059628
2.

Uridylation by TUT4 and TUT7 marks mRNA for degradation [TAIL-Seq]

(Submitter supplied) Uridylation occurs pervasively on mRNAs in mammals, yet its mechanism and significance remain unknown. Here we identify TUT4 and TUT7 (also known as ZCCHC11 and ZCCHC6, respectively) as the enzymes that uridylate mRNAs. Uridylation readily occurs on deadenylated mRNAs that are not associated with poly(A) binding protein (PABPC1) in cells. Consistently, purified TUT4 and TUT7 (TUT4/7) selectively uridylate RNAs with short A tails (< ~25 nt) while PABPC1 antagonizes uridylation of polyadenylated mRNAs in vitro. more...
Organism:
Homo sapiens
Type:
Other
Platforms:
GPL16791 GPL15520
39 Samples
Download data: TXT
Series
Accession:
GSE59627
ID:
200059627
3.

Illumina MiSeq (Homo sapiens)

Platform
Accession:
GPL15520
ID:
100015520
4.

TAIL-seq exp #7 siDIS3L2

Organism:
Homo sapiens
Source name:
TS7_siDIS3L2
Platform:
GPL15520
Series:
GSE59627 GSE59628
Download data: TXT
Sample
Accession:
GSM1440680
ID:
301440680
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Supplemental Content

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