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Items: 3

1.

The Mediator complex subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination

(Submitter supplied) The Mediator complex orchestrates multiple transcription factors with the Pol II apparatus for precise transcriptional control. However, its interplay with the surrounding chromatin remains poorly understood. Here, we analyze differential histone modifications between WT and MED23-/- (KO) cells and identify H2B mono-ubiquitination at lysine 120 (H2Bub) as a MED23-dependent histone modification. Using tandem affinity purification and mass spectrometry, we find that MED23 associates with the RNF20/40 complex, the enzyme for H2Bub, and show that this association is critical for the recruitment of RNF20/40 to chromatin. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL11002 GPL13112
10 Samples
Download data: WIG
Series
Accession:
GSE59518
ID:
200059518
2.

Illumina Genome Analyzer IIx (Mus musculus)

Platform
Accession:
GPL11002
ID:
100011002
3.

pol2_WT_ChIPSeq

Organism:
Mus musculus
Source name:
MEFs cells wildtype
Platform:
GPL11002
Series:
GSE59518
Download data: WIG
Sample
Accession:
GSM1438697
ID:
301438697
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