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Items: 3

1.

Identification of epigenetic barrier that prevents reprogramming in somatic cell nuclear transfer

(Submitter supplied) Mammalian oocytes can reprogram somatic cells into totipotent state, which allows animal cloning through somatic cell nuclear transfer (SCNT). However, the great majority of SCNT embryos fail to develop to term due to poorly defined reprogramming defects. Here we demonstrate that histone H3 lysine 9 trimethylation (H3K9me3) in donor nuclei is a major epigenetic barrier that prevents efficient nuclear reprogramming in mouse oocytes. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
14 Samples
Download data: TXT
Series
Accession:
GSE59073
ID:
200059073
2.

Illumina HiSeq 2500 (Mus musculus)

Platform
Accession:
GPL17021
ID:
100017021
3.

SCNT2C_Kdm4dmutOE_1_RNAseq

Organism:
Mus musculus
Source name:
Kdm4dmut-OE 2-cell SCNT embryos
Platform:
GPL17021
Series:
GSE59073
Download data
Sample
Accession:
GSM1426207
ID:
301426207
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