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Items: 3

1.

A Sox2 distal enhancer cluster regulates embryonic stem cell differentiation potential

(Submitter supplied) We report the effect on genome-wide gene expression after deletion of an enhancer region downstream of Sox2 in F1 ES cells. The Sox2 transcription factor must be robustly transcribed in embryonic stem (ES) cells to maintain pluripotency.  Reporter assays reveal novel enhancers, including two enhancers over 100 kb downstream (SRR107 and SRR111) which, through the formation of chromatin loops, localise to the Sox2 promoter in ES cells.  Using CRISPR/Cas9 we deleted a region containing these two enhancers, which we term the Sox2 control region (SCR). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL13112 GPL16417
12 Samples
Download data: BEDGRAPH
Series
Accession:
GSE58339
ID:
200058339
2.

Illumina MiSeq (Mus musculus)

Platform
Accession:
GPL16417
ID:
100016417
3.

Del_SCR_Cast_11 [Illumina MiSeq]

Organism:
Mus musculus
Source name:
embryonic stem cells
Platform:
GPL16417
Series:
GSE58339
Download data
Sample
Accession:
GSM1407415
ID:
301407415
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