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Items: 4

1.

Bromodomain protein BRD4 is required for estrogen receptor-dependent transcription and enhancer activation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL16791 GPL11154
38 Samples
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Series
Accession:
GSE55923
ID:
200055923
2.

Bromodomain protein BRD4 is required for estrogen receptor-dependent transcription and enhancer activation [RNA-Seq]

(Submitter supplied) The estrogen receptor-α (ERα) is a transcription factor which plays a critical role in controlling cell proliferation and tumorigenesis by recruiting various cofactors to estrogen response elements (EREs) to induce or repress gene transcription. A deeper understanding of these transcriptional mechanisms may uncover novel therapeutic targets for ERα-dependent cancers. Here we show for the first time that BRD4 regulates ERα−induced gene expression by affecting elongation-associated phosphorylation of RNA Polymerase II (RNAPII P-Ser2) and histone H2B monoubiquitination (H2Bub1). more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
12 Samples
Download data: CSV
3.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
4.

JQ1 Veh rep1

Organism:
Homo sapiens
Source name:
MCF7 breast cancer cells
Platform:
GPL11154
Series:
GSE55922 GSE55923
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Sample
Accession:
GSM1348549
ID:
301348549
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Supplemental Content

db=gds|term=GSM1348549[Accession]|query=1|qty=2|blobid=MCID_661f5abdd4af9b20896f7d12|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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