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Items: 3

1.

Generation 2.5 Antisense Oligonucleotides Targeting the Androgen Receptor and its Splice Variants Suppress Enzalutamide-Resistant Prostate Cancer Cell Growth

(Submitter supplied) Enzalutamide (ENZ) is a potent androgen receptor (AR) antagonist with activity in castration-resistant prostate cancer (CRPC); however, progression to ENZ-resistant (ENZ-R) CRPC frequently occurs with rising serum PSA levels, implicating AR full length (ARFL) or variants (AR-Vs) in disease progression. To define functional roles of ARFL and AR-Vs in ENZ-R CRPC, we designed 3 antisense oligonucleotides (ASO) targeting exon 1, intron 1, and exon 8 in AR pre-mRNA to knockdown either ARFL alone, or ARFL plus AR-Vs, and examined their respective effects in LNCaP-derived ENZ-R, as well as M12 and 22Rv1, cells. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL10123
6 Samples
Download data: TXT
Series
Accession:
GSE55345
ID:
200055345
2.

Agilent-022060 SurePrint G3 Human CGH Microarray 4x180K (Feature Number version)

(Submitter supplied) SurePrint G3 Human CGH Microarray 4x180K Arrays of this design have barcodes that begin with 16022060 or 2522060. Data table annotations based on build hg18:NCBI36:Mar2006. Orientation: Features are numbered numbered Left-to-Right, Top-to-Bottom as scanned by an Agilent scanner (barcode on the left, DNA on the back surface, scanned through the glass), matching the FeatureNum output from Agilent's Feature Extraction software. more...
Organism:
Homo sapiens
88 Series
1 Related Platform
1333 Samples
Download data
Platform
Accession:
GPL10123
ID:
100010123
3.

P252_ENZ-R

Organism:
Homo sapiens
Source name:
castrate-resistant prostate cancer cell line xenograft, ENZ resistant (channel 1) male reference DNA (Promega Corp. cat# G1471) (channel 2)
Platform:
GPL10123
Series:
GSE55345
Download data: TXT
Sample
Accession:
GSM1334482
ID:
301334482
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