GSM1325035[Accession] - GEO DataSets

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Items: 4

Select item 2000548431.

Acute depletion redefines the division of labor among DNA methyltransferases in methylating the human genome

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array; Methylation profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL13534 GPL6244 GPL11154
56 Samples

Download data: BED, BIGWIG, CEL, TXT

Series

Accession:: GSE54843

ID:: 200054843

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000548422.

Acute depletion redefines the division of labor among DNA methyltransferases in methylating the human genome [MBD-seq]

(Submitter supplied) Global patterns of DNA methylation, mediated by the DNA methyltransferases (DNMTs), are disrupted in all cancers by mechanisms that remain largely unknown, hampering their development as therapeutic targets. Combinatorial acute depltion of all DNMTs in a pluripotent human tumor cell line, followed by epigenome and transcriptome analysis, revealed DNMT functions in unprecedented detail. DNMT3B occupancy regulates methylation during differentiation, while an unexpected interplay was discovered in which DNMT1 and DNMT3B antithetically regulate methylation and hydroxymethylation in gene bodies, a finding confirmed in other cell types. more...