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Items: 3

1.

Expression data from human brain anterior cingulate cortex - including control samples and samples with major depression disorders (20 samples MD2_ACC)

(Submitter supplied) Major depressive disorder is a heterogeneous illness with a mostly uncharacterized pathology. Large scale gene expression (transcriptome) analysis and genome-wide association studies (GWAS) for single nucleotide polymorphisms have generated a considerable amount of gene- and disease-related information, but heterogeneity and various sources of noise have limited the discovery of disease mechanisms. As systematic dataset integration is becoming essential, we developed methods and performed meta-clustering of gene coexpression links in 11 transcriptome studies from postmortem brains of human subjects with major depressive disorder (MDD) and non-psychiatric control subjects. We next sought enrichment in the top 50 meta-analyzed coexpression modules for genes otherwise identified by GWAS for various sets of disorders. One coexpression module of 88 genes was consistently and significantly associated with GWAS for MDD, other neuropsychiatric disorders and brain functions, and for medical illnesses with elevated clinical risk of depression, but not for other diseases (See publication for details).
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
20 Samples
Download data: TXT
Series
Accession:
GSE54562
ID:
200054562
2.

Illumina HumanHT-12 V3.0 expression beadchip

(Submitter supplied) The HumanHT-12 V3.0 Expression BeadChip features up-to-date content derived from the National Center for Biotechnology Information Reference Sequence (NCBI RefSeq) database (Build 36.2, Release 22). Please use the GEO Data Submission Report Plug-in v1.0 for Gene Expression which may be downloaded from https://icom.illumina.com/icom/software.ilmn?id=234 to format the normalized and raw data. These should be submitted as part of a GEOarchive. more...
Organism:
Homo sapiens
13 DataSets
542 Series
1 Related Platform
26115 Samples
Download data: BGX
Platform
Accession:
GPL6947
ID:
100006947
3.

Control matched sample pair anterior cingulate cortex MD2_ACC #5

Organism:
Homo sapiens
Source name:
Control sample, brain anterior cingulate cortex
Platform:
GPL6947
Series:
GSE54562
Download data
Sample
Accession:
GSM1318881
ID:
301318881
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