GSM1315594[Accession] - GEO DataSets

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Items: 4

Select item 2000544541.

Genome-wide and single-cell analyses reveal target gene context-dependent relationship between Crebbp recruitment and both constitutive and signal-responsive gene expression.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11002 GPL11180
20 Samples

Download data: BW, CEL

Series

Accession:: GSE54454

ID:: 200054454

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000544522.

Expression data from wild type and CBP/p300 null MEFs +/- 3hr treatment with 100uM dipyridyl (DP)

(Submitter supplied) Genome-wide distribution of histone H3K18 and H3K27 acetyltransferases, Crebbp (CBP) and Ep300 (p300), is used to map enhancers and promoters, but whether these elements functionally require CBP/p300 remains largely uncertain. We investigated this relationship by comparing genomic CBP recruitment with gene expression in wild type and CBP/p300 double-knockout fibroblasts. ChIP-seq revealed nearby CBP recruitment for 20 percent of constitutively expressed genes, but surprisingly, three-quarters of these were unaffected or slightly activated by CBP/p300 deletion. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11180
12 Samples

Download data: CEL

Series

Accession:: GSE54452

ID:: 200054452

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000111803.

[HT_MG-430_PM] Affymetrix HT MG-430 PM Array Plate

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html Protocol: see manufacturer's web site