GSM1303239[Accession] - GEO DataSets

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Items: 3

Select item 2000538961.

Pre-BCR Signaling induce IgK Locus Accessibility by functional redistribution of Enhancer-mediated chromatin Interactions

(Submitter supplied) During B cell development the precursor B cell receptor (pre-BCR) checkpoint is thought to increase immunoglobulin k light chain (Igk) locus accessibility to the V(D)J recombinase. Accordingly, pre-B cells lacking the pre-BCR signaling molecules Btk or Slp65 showed reduced germline Vk transcription. To investigate whether pre-BCR signaling modulates Vk accessibility through enhancer-mediated Igk locus topology, we performed chromosome conformation capture and sequencing analyses. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
19 Samples

Download data: CEL

Series

Accession:: GSE53896

ID:: 200053896

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000062462.

[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site