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Items: 3

1.

Stage-specific control of early B cell development by the transcription factor Ikaros

(Submitter supplied) Ikaros is an essential regulator of lymphopoiesis. Here, we studied the B-cell-specific function of Ikaros by conditional Ikzf1 inactivation in pro-B cells. B-cell development was arrested at an aberrant ‘pro-B’ cell stage characterized by increased cell adhesion and loss of pre-B cell receptor signaling. Ikaros was found to activate genes coding for pre-BCR signal transducers and to repress genes involved in the downregulation of pre-BCR signaling and upregulation of the integrin signaling pathway. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL11002 GPL13112
48 Samples
Download data: BW, TXT
Series
Accession:
GSE53595
ID:
200053595
2.

Illumina HiSeq 2000 (Mus musculus)

Platform
Accession:
GPL13112
ID:
100013112
3.

RNA-seq Ikaros KD Ren713 control pre-pro-B 15283

Organism:
Mus musculus
Source name:
Pre-pro-B cell
Platform:
GPL13112
Series:
GSE53595
Download data: TXT
Sample
Accession:
GSM1296565
ID:
301296565
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