GSM1272326[Accession] - GEO DataSets

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Items: 4

Select item 2000525951.

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation (4C-seq)

(Submitter supplied) Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin remodeling complex for their survival and aberrant self-renewal potential. While Brg1, an ATPase subunit of SWI/SNF, is known to suppress tumor formation in several cancer types, we found that leukemia cells instead rely on Brg1 to support their oncogenic transcriptional program, which includes Myc as one of its key targets. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL16417
6 Samples

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Accession:: GSE52595

ID:: 200052595

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000522792.

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Other