(Submitter supplied) Embryonic stem cell (ESC) self-renewal and pluripotency is controlled by the coordinated action of transcription factors and chromatin regulators. Compared to the pluripotency transcription factors, the function of the chromatin regulators, especially the ATP-dependent chromatin remodelers, remains poorly understood in ESCs. Here, we show that INO80, a SWI/SNF family chromatin remodeling complex, is essential for ESC self-renewal, pluripotency, somatic cell reprogramming, and embryonic development.
more...- Organism:
- Mus musculus
- Type:
- Genome binding/occupancy profiling by high throughput sequencing
- Platform:
- GPL16417
- 12 Samples
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