(Submitter supplied) Murine and non-human primates (e.g. rhesus monkeys) represent excellent model systems to study human health and disease. However, use of these model systems for genomic studies is limited, particularly with array-based tools, as most have only been developed to survey the human genome. Here we present the optimization of a widely used human DNA methylation array, designed to detect 5-methylcytosine (5-mC), and show that non-human data generated using the optimized array reproducibly distinguishes tissue types within and between chimpanzee, rhesus, and mouse, with correlations near the human DNA level (R2 > 0.99).
more...- Organism:
- Pan troglodytes; Mus musculus; Macaca mulatta; Homo sapiens
- Type:
- Methylation profiling by genome tiling array
- Platform:
- GPL13534
- 61 Samples
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