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Items: 3

1.

Expression data from JQ1 (0.2 uM) treated tamoxifen-resistant MCF7 cells

(Submitter supplied) Estrogen signaling pathway is critical for breast cancer development and has remained the major adjuvant therapeutic target for this disease. Tamoxifen has been used in clinic for many years to treat ER-positive breast cancer. However a great many (30%) suffer relapse due to drug resistance. In this study, the bromodomain inhibitor JQ1 was found to down-regulate ERalpha gene expression and have anti-tumor effect in cultured tamoxifen-resisant breast cancer cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10739
6 Samples
Download data: CEL
Series
Accession:
GSE49124
ID:
200049124
2.

[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [probe set (exon) version]

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html #%create_date=Thu Jan 21 16:38:27 2010 PST #%chip_type=HuGene-1_0-st-v1 #%lib_set_name=HuGene-1_0-st #%lib_set_version=v1 #%genome-species=Homo sapiens #%genome-version=hg19 #%genome-version-ucsc=hg19 #%genome-version-ncbi=GRCh37 #%genome-version-create_date=2009-02-00 #%netaffx-annotation-date=2009-11-23 #%netaffx-annotation-netaffx-build=30.1 Protocol: See manufacturer's web site
Organism:
Homo sapiens
57 Series
664 Samples
Download data
Platform
Accession:
GPL10739
ID:
100010739
3.

DMSO treatment, biological rep3

Organism:
Homo sapiens
Source name:
DMSO-treated MCF7 cells, 24 hours
Platform:
GPL10739
Series:
GSE49124
Download data: CEL
Sample
Accession:
GSM1194052
ID:
301194052
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