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Items: 4

1.

Targeting H3K4 methylation as a therapeutic strategy for Huntington's disease

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL13112 GPL11002
32 Samples
Download data: BW, RPKM
Series
Accession:
GSE48963
ID:
200048963
2.

Targeting H3K4 methylation as a therapeutic strategy for Huntington's disease (ChIP-seq)

(Submitter supplied) Transcriptional dysregulation is an early feature of Huntington's disease (HD). We observed gene-specific changes in H3K4me3 at transcriptionally repressed promoters in R6/2 mouse and human HD brain. Genome-wide analysis showed a novel chromatin signature for this mark. Reducing the levels of the H3K4 demethylase SMCX/Jarid1c in primary neurons reversed down-regulation of key neuronal genes caused by mutant Huntingtin (Htt) expression. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL11002 GPL13112
8 Samples
Download data: BW
Series
Accession:
GSE48960
ID:
200048960
3.

Illumina HiSeq 2000 (Mus musculus)

Platform
Accession:
GPL13112
ID:
100013112
4.

ChIP_WT_H3K4me3_8wks_ctx_rep1_rep2

Organism:
Mus musculus
Source name:
R6/2 wildtype littermate, cortex, 8 weeks
Platform:
GPL13112
Series:
GSE48960 GSE48963
Download data: BW
Sample
Accession:
GSM1187623
ID:
301187623
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