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Items: 4

1.

Targeted disruption of Hotair leads to homeotic transformation and de-repression of imprinted genes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array
Platforms:
GPL11002 GPL1261
18 Samples
Download data: BEDGRAPH, CEL
Series
Accession:
GSE48007
ID:
200048007
2.

Targeted disruption of Hotair leads to homeotic transformation and de-repression of imprinted genes [RNA-Seq, ChIP-Seq]

(Submitter supplied) Long noncoding RNAs (lncRNAs) are thought to be prevalent regulators of gene expression, but the consequences of lncRNA inactivation in vivo are mostly unknown. Here we show that targeted deletion of mouse Hotair lncRNA leads to de-repression of hundreds of genes, resulting in homeotic transformation of the spine and malformation of metacarpal-carpal bones. RNA-seq and conditional inactivation reveal an ongoing requirement of Hotair to repress HoxD genes and multiple imprinted loci such as Dlk1-Meg3 and Igf2-H19. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11002
12 Samples
Download data: BEDGRAPH, TXT
Series
Accession:
GSE48005
ID:
200048005
3.

Illumina Genome Analyzer IIx (Mus musculus)

Platform
Accession:
GPL11002
ID:
100011002
4.

rnaseq ko1

Organism:
Mus musculus
Source name:
neonatal tail tip fibroblasts, Hotair knockout
Platform:
GPL11002
Series:
GSE48005 GSE48007
Download data
Sample
Accession:
GSM1164896
ID:
301164896
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