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Items: 4

1.

Runx1 targets in early B-cell progenitors

(Submitter supplied) The t(12;21) chromosomal translocation, targeting the gene encoding the RUNX1 transcription factor, is observed in 25% of pediatric acute lymphoblastic leukemia (ALL) and is an initiating event in the disease. To elucidate the mechanism by which RUNX1 disruption initiates leukemogenesis, we investigated its normal role in murine B-cell development. Gene expression analysis and genome-wide Runx1-occupancy studies support the hypothesis that Runx1 reinforces the transcription factor network in B-cell progenitors governing early B-cell survival and development .
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array
Platforms:
GPL11002 GPL11202 GPL7202
10 Samples
Download data: TXT
Series
Accession:
GSE45425
ID:
200045425
2.

Gene expression analysis to identify Runx1 target genes in B-cell progenitors

(Submitter supplied) The t(12;21) chromosomal translocation, targeting the gene encoding the RUNX1 transcription factor, is observed in 25% of pediatric acute lymphoblastic leukemia (ALL) and is an initiating event in the disease. To elucidate the mechanism by which RUNX1 disruption initiates leukemogenesis, we investigated its normal role in murine B-cell development. Gene expression analysis and genome-wide Runx1-occupancy studies support the hypothesis that Runx1 reinforces the transcription factor network in B-cell progenitors governing early B-cell survival and development .
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL11202 GPL7202
8 Samples
Download data: TXT
Series
Accession:
GSE45424
ID:
200045424
3.

Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)

(Submitter supplied) *** The ID column includes the Agilent Probe Names. A different version of this platform with the Agilent Feature Extraction feature numbers in the ID column is assigned accession number GPL10333. Protocol: see manufacturer's web site at http://www.agilent.com/
Organism:
Mus musculus
333 Series
1 Related Platform
4118 Samples
Download data
Platform
Accession:
GPL11202
ID:
100011202
4.

proB-cell line_ERt2_OHT

Organism:
Mus musculus
Source name:
cell line BMiFLT3(15-3)
Platform:
GPL11202
Series:
GSE45424 GSE45425
Download data: TXT
Sample
Accession:
GSM1104069
ID:
301104069
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