GSM1056072[Accession] - GEO DataSets

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Items: 3

Select item 2000430601.

Genomic analysis of relapsed Acute Lymphoblastic Leukaemia in children

(Submitter supplied) Identification of de novo copy number abnormalities arising in relapsed paediatric ALL in matched presentation and relapse samples. We identified deletions of BACH2, (BTB and CNC homology 1, basic leucine zipper transcription factor 2) at relapse. To study the role of Bach2 in pre-B ALL in a genetic experiment, we transformed pre-B cells from Bach2–/– mice with BCR-ABL1. Our findings identify Bach2 as a novel tumor suppressor upstream of p53 in pre-B ALL.

Organism:: Homo sapiens

Type:: SNP genotyping by SNP array; Genome variation profiling by SNP array

Platforms:: GPL3718 GPL3720
64 Samples

Download data: CEL, CHP, TXT

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Accession:: GSE43060

ID:: 200043060

PubMed Full text in PMC Similar studies

Select item 1000037182.

[Mapping250K_Nsp] Affymetrix Mapping 250K Nsp SNP Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html The GeneChip® Human Mapping 500K Array Set provides consistently high coverage across different populations. It is comprised of two arrays, each capable of genotyping on average 250,000 SNPs (approximately 262,000 for Nsp arrays and 238,000 for Sty arrays). more...