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Items: 3

1.

TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells

(Submitter supplied) TRIM28 (KAP1 - KRAB-associated protein 1) is critical for the silencing of endogenous retroviruses (ERVs) in embryonic stem (ES) cells. Here, we reveal that an essential impact of this process is the protection of cellular gene expression in early embryos from perturbation by cis-acting activators contained within these genetic invaders. In TRIM28-depleted ES cells, repressive chromatin marks at ERVs are replaced by histone modifications typical of active enhancers, stimulating transcription of nearby cellular genes, notably those harboring bivalent promoters. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL9250 GPL13112
18 Samples
Download data: BED, TXT, XLS
Series
Accession:
GSE41903
ID:
200041903
2.

Illumina HiSeq 2000 (Mus musculus)

Platform
Accession:
GPL13112
ID:
100013112
3.

H3K27ac ChIP: KAP1 WT IP

Organism:
Mus musculus
Source name:
H3K27ac ChIP: KAP1 WT IP
Platform:
GPL13112
Series:
GSE41903
Download data
Sample
Accession:
GSM1032194
ID:
301032194
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db=gds|term=GSM1032194[Accession]|query=1|qty=2|blobid=MCID_65ddcbb7a642ff6770e5d0de|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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