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Items: 10

1.

Resistance to Palbociclib involves multiple mechanisms amenable to targeting with drug holidays or drug switching to improve therapeutic outcome [Affymetrix]

(Submitter supplied) Combination of CDK4/6 inhibitors and endocrine therapy has been shown to improve clinical outcome in advanced estrogen receptor-positive breast cancer. However, not all patients will benefit and relapse is inevitable making the identification of new therapeutic strategies/biomarkers of particular importance.
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array; SNP genotyping by SNP array
Platform:
GPL6801
8 Samples
Download data: CEL, CHP
Series
Accession:
GSE99002
ID:
200099002
2.

[GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 (ucsc=hg18; ncbi=NCBI36) August 01, 2012: annotation table updated with netaffx build 32 (ucsc=hg19; ncbi=GRCh37) Protocol: see manufacturer's web site The new Affymetrix® Genome-Wide Human SNP Array 6.0 features 1.8 million genetic markers, including more than 906,600 single nucleotide polymorphisms (SNPs) and more than 946,000 probes for the detection of copy number variation. more...
Organism:
Homo sapiens
404 Series
22859 Samples
Download data
Platform
Accession:
GPL6801
ID:
100006801
3.

T47D-LTED 991R

Organism:
Homo sapiens
Source name:
T47D-LTED, resistant to estrogen deprivation, treated with Palbociclib (CDK4/6 inhibitor) until became Palbociclib-resistant
Platform:
GPL6801
Series:
GSE99002 GSE99003
Download data: CEL, CHP
Sample
Accession:
GSM2629883
ID:
302629883
4.

T47D-LTED

Organism:
Homo sapiens
Source name:
T47D-LTED, resistant to estrogen deprivation
Platform:
GPL6801
Series:
GSE99002 GSE99003
Download data: CEL, CHP
Sample
Accession:
GSM2629882
ID:
302629882
5.

T47D 991R

Organism:
Homo sapiens
Source name:
T47D in E2 treated with Palbociclib (CDK4/6 inhibitor) until resistant
Platform:
GPL6801
Series:
GSE99002 GSE99003
Download data: CEL, CHP
Sample
Accession:
GSM2629881
ID:
302629881
6.

T47D

Organism:
Homo sapiens
Source name:
T47D under E2 maintenance
Platform:
GPL6801
Series:
GSE99002 GSE99003
Download data: CEL, CHP
Sample
Accession:
GSM2629880
ID:
302629880
7.

MCF7-LTED 991R

Organism:
Homo sapiens
Source name:
MCF7-LTED, resistant to estrogen deprivation, treated with Palbociclib (CDK4/6 inhibitor) until became Palbociclib-resistant
Platform:
GPL6801
Series:
GSE99002 GSE99003
Download data: CEL, CHP
Sample
Accession:
GSM2629879
ID:
302629879
8.

MCF7-LTED

Organism:
Homo sapiens
Source name:
MCF7-LTED, resistant to estrogen deprivation
Platform:
GPL6801
Series:
GSE99002 GSE99003
Download data: CEL, CHP
Sample
Accession:
GSM2629878
ID:
302629878
9.

wt-MCF7 991R

Organism:
Homo sapiens
Source name:
MCF7 in E2 treated with Palbociclib (CDK4/6 inhibitor) until resistant
Platform:
GPL6801
Series:
GSE99002 GSE99003
Download data: CEL, CHP
Sample
Accession:
GSM2629877
ID:
302629877
10.

wt-MCF7

Organism:
Homo sapiens
Source name:
MCF7 under E2 maintenance
Platform:
GPL6801
Series:
GSE99002 GSE99003
Download data: CEL, CHP
Sample
Accession:
GSM2629876
ID:
302629876
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Supplemental Content

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