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Items: 9

1.

A multipartite enhancer ensemble coordinates pleiotropic developmental functions of Indian hedgehog

(Submitter supplied) Copy number variations (CNVs) including enhancers frequently appear associated with disease, induced by pathomechanisms that are poorly understood. Here we show through transgenic reporter and genome editing studies in mice that Indian hedgehog (Ihh) is regulated by a constellation of enhancers of unusual complexity and we uncover how duplications within this enhancer architecture cause phenotypes reminiscent of those observed in human patients. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL17021 GPL18480
6 Samples
Download data: BEDGRAPH
Series
Accession:
GSE95062
ID:
200095062
2.

Illumina HiSeq 1500 (Mus musculus)

Platform
Accession:
GPL18480
ID:
100018480
3.

Illumina HiSeq 2500 (Mus musculus)

Platform
Accession:
GPL17021
ID:
100017021
4.

4C_WT_IhhTSS_rep2

Organism:
Mus musculus
Source name:
E14.5 digit forelimb, WT
Platform:
GPL17021
Series:
GSE95062
Download data: BEDGRAPH
Sample
Accession:
GSM2495555
ID:
302495555
5.

4C_WT_IhhTSS_rep1

Organism:
Mus musculus
Source name:
E14.5 digit forelimb, WT
Platform:
GPL17021
Series:
GSE95062
Download data: BEDGRAPH
Sample
Accession:
GSM2495554
ID:
302495554
6.

4C_Dup-syn_IhhTSS_rep_2

Organism:
Mus musculus
Source name:
E14.5 digit forelimb, Dup-syn
Platform:
GPL18480
Series:
GSE95062
Download data: BEDGRAPH
Sample
Accession:
GSM2495559
ID:
302495559
7.

4C_Dup-syn_IhhTSS_rep_1

Organism:
Mus musculus
Source name:
E14.5 digit forelimb, Dup-syn
Platform:
GPL18480
Series:
GSE95062
Download data: BEDGRAPH
Sample
Accession:
GSM2495558
ID:
302495558
8.

4C_Dup-int_IhhTSS_rep2

Organism:
Mus musculus
Source name:
E14.5 digit forelimb, Dup-int
Platform:
GPL18480
Series:
GSE95062
Download data: BEDGRAPH
Sample
Accession:
GSM2495557
ID:
302495557
9.

4C_Dup-int_IhhTSS_rep1

Organism:
Mus musculus
Source name:
E14.5 digit forelimb, Dup-int
Platform:
GPL18480
Series:
GSE95062
Download data: BEDGRAPH
Sample
Accession:
GSM2495556
ID:
302495556
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Supplemental Content

db=gds|term=GSE95062[Accession]|query=1|qty=2|blobid=MCID_6648b40ef630692827420edb|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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