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Items: 15

1.

A novel requirement for Drosha in maintenance of mammalian CG methylation

(Submitter supplied) Using a protein interaction screen, we identify the Microprocessor component Drosha as a novel Dnmt1-interactor. Drosha-deficient ES cells display genomic hypomethylation which is not accounted for by changes in the levels of Dnmt proteins. Both genetic and transfection studies show that Drosha stimulates Dnmt1 methyltransferase activity. We identify two transcripts that are specifically upregulated in Drosha but not Dicer-deficient ES cells. more...
Organism:
Mus musculus
Type:
Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL19057 GPL17021
12 Samples
Download data: TSV, TXT
Series
Accession:
GSE86907
ID:
200086907

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina NextSeq 500 (Mus musculus)

Organism:
Mus musculus
10521 Series
299959 Samples
Download data
Platform
Accession:
GPL19057
ID:
100019057

3.

Illumina HiSeq 2500 (Mus musculus)

Organism:
Mus musculus
11269 Series
301398 Samples
Download data
Platform
Accession:
GPL17021
ID:
100017021

4.

Dnmt1-deficient ES cells derived from J1 ES cells

Organism:
Mus musculus
Source name:
J1_Dnmt1-deficient_ESCs
Platform:
GPL19057
Series:
GSE86907
Download data: TSV
Sample
Accession:
GSM2310234
ID:
302310234

SRA Run Selector

5.

Drosha-deficient ES cells, derived from AB1 ES cells

Organism:
Mus musculus
Source name:
AB1_Drosha-deficient_ESCs
Platform:
GPL19057
Series:
GSE86907
Download data: TSV
Sample
Accession:
GSM2310233
ID:
302310233

SRA Run Selector

6.

WT, AB1 (129Sv/Ev) ES cells

Organism:
Mus musculus
Source name:
AB1_WT_ESCs
Platform:
GPL19057
Series:
GSE86907
Download data: TSV
Sample
Accession:
GSM2310232
ID:
302310232

SRA Run Selector

7.

Dnmt1-deficient ES cells short RNA

Organism:
Mus musculus
Source name:
Dnmt1-deficient ES cells
Platform:
GPL17021
Series:
GSE86907
Download data
Sample
Accession:
GSM2322001
ID:
302322001

SRA Run Selector

8.

Dnmt1-deficient ES cells mRNA

Organism:
Mus musculus
Source name:
Dnmt1-deficient ES cells
Platform:
GPL17021
Series:
GSE86907
Download data
Sample
Accession:
GSM2322000
ID:
302322000

SRA Run Selector

9.

Dnmt1-deficient ES cells total RNA

Organism:
Mus musculus
Source name:
Dnmt1-deficient ES cells
Platform:
GPL17021
Series:
GSE86907
Download data
Sample
Accession:
GSM2321999
ID:
302321999

SRA Run Selector

10.

Drosha-deficient ES cells short RNA

Organism:
Mus musculus
Source name:
Drosha-deficient ES cells
Platform:
GPL17021
Series:
GSE86907
Download data
Sample
Accession:
GSM2321998
ID:
302321998

SRA Run Selector

11.

Drosha-deficient ES cells mRNA

Organism:
Mus musculus
Source name:
Drosha-deficient ES cells
Platform:
GPL17021
Series:
GSE86907
Download data
Sample
Accession:
GSM2321997
ID:
302321997

SRA Run Selector

12.

Drosha-deficient ES cells total RNA

Organism:
Mus musculus
Source name:
Drosha-deficient ES cells
Platform:
GPL17021
Series:
GSE86907
Download data
Sample
Accession:
GSM2321996
ID:
302321996

SRA Run Selector

13.

WT ES cells short RNA

Organism:
Mus musculus
Source name:
WT ES cells
Platform:
GPL17021
Series:
GSE86907
Download data
Sample
Accession:
GSM2321995
ID:
302321995

SRA Run Selector

14.

WT ES cells mRNA

Organism:
Mus musculus
Source name:
WT ES cells
Platform:
GPL17021
Series:
GSE86907
Download data
Sample
Accession:
GSM2321994
ID:
302321994

SRA Run Selector

15.

WT ES cells total RNA

Organism:
Mus musculus
Source name:
WT ES cells
Platform:
GPL17021
Series:
GSE86907
Download data
Sample
Accession:
GSM2321993
ID:
302321993

SRA Run Selector

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