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Items: 1 to 20 of 41

1.

MEK inhibition profoundly reprograms myogenic super enhancers in mutant-RAS driven Rhabdomyosarcoma

(Submitter supplied) Trametinib-treated rhabdomyosarcoma cells undergo transcriptional reprogramming akin to myogenic differentiation. This reprogramming is induced by loss of ERK-mediated inhibition of MYOG expression. Restoration of MYOG allows establishment of super-enhancers at genes expressed by terminally differentiated myotubes. Our findings demonstrate that aberrant MAP kinase activity blocks differentiation in rhabdomyosarcoma and highlight trametinib as a potential therapeutic for RAS-mutated rhabdomyosarcoma.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL11154 GPL18573
38 Samples
Download data: BED
Series
Accession:
GSE85169
ID:
200085169
2.

Illumina NextSeq 500 (Homo sapiens)

Platform
Accession:
GPL18573
ID:
100018573
3.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
4.

CTR T48 Pol2S2pAMR

Organism:
Homo sapiens
Source name:
RMS cell line, mutant HRAS
Platform:
GPL18573
Series:
GSE85169 GSE85171
Download data: BED
Sample
Accession:
GSM3103107
ID:
303103107
5.

CTR D48 Pol2S2pAMR

Organism:
Homo sapiens
Source name:
RMS cell line, mutant HRAS
Platform:
GPL18573
Series:
GSE85169 GSE85171
Download data: BED
Sample
Accession:
GSM3103106
ID:
303103106
6.

CTR T48 MYCy69

Organism:
Homo sapiens
Source name:
RMS cell line, mutant HRAS
Platform:
GPL18573
Series:
GSE85169 GSE85171
Download data: BED
Sample
Accession:
GSM3103105
ID:
303103105
7.

CTR D48 MYCy69

Organism:
Homo sapiens
Source name:
RMS cell line, mutant HRAS
Platform:
GPL18573
Series:
GSE85169 GSE85171
Download data: BED
Sample
Accession:
GSM3103104
ID:
303103104
8.

CTR T48 PolII

Organism:
Homo sapiens
Source name:
RMS cell line, mutant HRAS
Platform:
GPL18573
Series:
GSE85169 GSE85171
Download data: BED
Sample
Accession:
GSM2259158
ID:
302259158
9.

CTR D48 PolII

Organism:
Homo sapiens
Source name:
RMS cell line, mutant HRAS
Platform:
GPL18573
Series:
GSE85169 GSE85171
Download data: BED
Sample
Accession:
GSM2259157
ID:
302259157
10.

CTR T48 MYOG

Organism:
Homo sapiens
Source name:
RMS cell line, mutant HRAS
Platform:
GPL18573
Series:
GSE85169 GSE85171
Download data: BED
Sample
Accession:
GSM2259156
ID:
302259156
11.

CTR D48 MYOG

Organism:
Homo sapiens
Source name:
RMS cell line, mutant HRAS
Platform:
GPL18573
Series:
GSE85169 GSE85171
Download data: BED
Sample
Accession:
GSM2259155
ID:
302259155
12.

CTR D48 MYOD1 rep 2

Organism:
Homo sapiens
Source name:
RMS cell line, mutant HRAS
Platform:
GPL18573
Series:
GSE85169 GSE85171
Download data: BED
Sample
Accession:
GSM2259154
ID:
302259154
13.

CTR D48 MYOD1 rep 1

Organism:
Homo sapiens
Source name:
RMS cell line, mutant HRAS
Platform:
GPL18573
Series:
GSE85169 GSE85171
Download data: BED
Sample
Accession:
GSM2259153
ID:
302259153
14.

CTR T48 MYOD1

Organism:
Homo sapiens
Source name:
RMS cell line, mutant HRAS
Platform:
GPL18573
Series:
GSE85169 GSE85171
Download data: BED
Sample
Accession:
GSM2259152
ID:
302259152
15.

CTR D48 input rep 2

Organism:
Homo sapiens
Source name:
RMS cell line, mutant HRAS
Platform:
GPL18573
Series:
GSE85169 GSE85171
Download data
Sample
Accession:
GSM2259148
ID:
302259148
16.

CTR D48 input rep 1

Organism:
Homo sapiens
Source name:
RMS cell line, mutant HRAS
Platform:
GPL18573
Series:
GSE85169 GSE85171
Download data
Sample
Accession:
GSM2259147
ID:
302259147
17.

CTR T48 input

Organism:
Homo sapiens
Source name:
RMS cell line, mutant HRAS
Platform:
GPL18573
Series:
GSE85169 GSE85171
Download data
Sample
Accession:
GSM2259146
ID:
302259146
18.

CTR D48 H3K4me3

Organism:
Homo sapiens
Source name:
RMS cell line, mutant HRAS
Platform:
GPL18573
Series:
GSE85169 GSE85171
Download data: BED
Sample
Accession:
GSM2259145
ID:
302259145
19.

CTR D48 H3K4me2

Organism:
Homo sapiens
Source name:
RMS cell line, mutant HRAS
Platform:
GPL18573
Series:
GSE85169 GSE85171
Download data: BED
Sample
Accession:
GSM2259144
ID:
302259144
20.

CTR D48 H3K4me1

Organism:
Homo sapiens
Source name:
RMS cell line, mutant HRAS
Platform:
GPL18573
Series:
GSE85169 GSE85171
Download data: BED
Sample
Accession:
GSM2259143
ID:
302259143
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